Sodium Acetate 100 mM, pH 4.5
Ready-to-use 100 mM sodium acetate buffer at pH 4.5 for cation-exchange and formulation. · GMP catalogue product · CT-76451
Sodium Acetate 100 mM, pH 4.5 is a defined, ready-to-use acetate buffer. In downstream processing it serves as a cation-exchange (CEX) equilibration and wash buffer and as a base for UF/DF and formulation. With a fixed composition and pH it is used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy.
Why
- Defined acetate base - Fixed pH 4.5 ± 0.2.
- Chromatography & formulation - CEX plus UF/DF and formulation.
- GMP grade - Catalogue GMP quality, released per lot.
- Multi-application - Used across antibody, vaccine and C&G downstream.
Specification
| Composition | 100 mM sodium acetate |
| pH | 4.5 ± 0.2 |
| Form | Ready-to-use buffer |
| Storage | 15-25 °C (room temperature) |
| Grade | GMP |
Ordering
| Grade | Article No. | Pack size |
|---|---|---|
| GMP | CT-76451 | 500 ml |
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Other pack sizes are available on request.
In the downstream process - by application
Sodium Acetate 100 mM, pH 4.5 is used at the following process steps across the four biologics platforms:
Monoclonal antibodies
- Cation exchange (CEX) - equilibration and wash buffer base.
- UF/DF and formulation - acetate buffer base.
Vaccines
- Ion-exchange chromatography - buffer base.
- Formulation - buffer base.
mRNA
- LNP formulation - low-pH mixing buffer (acetate system).
- Formulation - buffering.
Cell & gene therapy
- Cation / ion exchange - buffer base.
- Formulation - buffer base.
Frequently asked questions
What is Sodium Acetate 100 mM, pH 4.5 used for?
It is used for cation-exchange (CEX) equilibration/wash and as a base for UF/DF and formulation.
What is the pH?
It is supplied at a fixed pH of 4.5 ± 0.2.
Is it multi-application?
Yes, it is used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy downstream.
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