RNase/DNase Neutralizer, Nuclease Decontamination solution
Process reagent · RUO (P10-61500) · RUO (P10-61000) · RUO (P10-65000C)
RNase/DNase Neutralizer, Nuclease Decontamination solution inactivates residual nucleases to protect nucleic-acid workflows, analytics and sensitive downstream steps from contaminating enzymatic activity.
One catalogue quality. RNase/DNase Neutralizer, Nuclease Decontamination solution is a RUO product (P10-61500), manufactured or assured by PAN-Celltech and released against a defined quality-control panel on every lot.
Why
- Nuclease inactivation – protects RNA/DNA workflows.
- Analytics protection – reduces enzymatic background.
- Ready to use – simple neutralisation step.
Specification
| Composition | Nuclease-neutralising reagent |
| Form | Solution |
| Grade | RUO |
| Storage | Room temperature (15-25 °C), protected from light; do not store below room temperature |
Ordering
In the process – by application (upstream & downstream)
RNase/DNase Neutralizer, Nuclease Decontamination solution is used at the following process steps across the biologics platforms it supports:
Monoclonal antibodies
- Cell Bank Management & Thaw / Cryorecovery – Surface and equipment decontamination; eliminates RNase/DNase from thaw area, laminar flow hood, vessels.
- Harvest & Clarification – Decontamination of harvest equipment, vessels and surfaces; eliminates RNase/DNase.
Cell & gene therapy
- Cell Bank Management & Thaw – Surface / equipment decontamination.
mRNA
- Template DNA Preparation – Surface / equipment decontamination.
Liposomes & LNP
- Aqueous / buffer preparation – surface / equipment decontamination for nucleic-acid payloads.
Frequently asked questions
In which grade is RNase/DNase Neutralizer, Nuclease Decontamination solution available?
It is available as a RUO product in three pack sizes: P10-61500 (500 ml), P10-61000 (1,000 ml) and P10-65000C (5 L); a GMP grade is not available.
Which processes is this product used in?
RNase/DNase Neutralizer, Nuclease Decontamination solution is used across the PAN monoclonal antibody, cell & gene therapy, mRNA and liposome & LNP processes. See "In the process – by application (upstream & downstream)" above for the specific steps in each.
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