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Upstream & Downstream

Pluronic® F-68 10 %, GMP grade

Process liquid / additive · RUO (P08-02100) · GMP (CT-02110)

RUO · P08-02100
GMP · CT-02110
Upstream · USP
Downstream · DSP

Pluronic® F-68 10 % – a non-ionic surfactant that protects cells from shear stress in suspension and bioreactor culture and during ultrafiltration.

Catalogue and GMP grade. Pluronic® F-68 10 % is a RUO product (P08-02100); a matched GMP grade (CT-02110) is also available. Both are manufactured or assured by PAN-Celltech and released against a defined quality-control panel on every lot.

Why

  • Shear protection – for suspension and bioreactor systems.
  • GMP grade – for regulated manufacture.
  • Non-ionic surfactant – 10 % solution.

Specification

Composition 10 % Poloxamer 188 (Pluronic® F-68)
Form Solution
Grade RUO and GMP
Storage 15-25 °C (room temperature)

Ordering

Grade Art. No. Pack size To Shop
RUO P08-02100 100 ml
GMP CT-02110 100 ml

Other pack sizes on request.

Request a quote
Beyond compendial – on request. Like every PAN process liquid, Pluronic® F-68 10 % can be prepared with WFI Beyond – Water for Injection engineered beyond the Ph. Eur./USP monograph – for the most demanding endotoxin and purity requirements. Available on request.

In the process – by application (upstream & downstream)

Pluronic® F-68 10 % is used at the following process steps across the biologics platforms it supports:

Monoclonal antibodies

  • CHO – Shear protectant in stirred bioreactors and shake flasks. Not needed for HybridBoost/ISF-1 (surfactant built in).
  • HEK – Shear protectant in stirred bioreactors and shake flasks. Not needed for HybridBoost/ISF-1 (surfactant built in).
  • Hybridoma – Shear protectant in stirred bioreactors and shake flasks. Not needed for HybridBoost/ISF-1 (surfactant built in).
  • Bioreactor Production (Fed-batch / Perfusion) – Continuous shear protection in sparged bioreactors (CHO/HEK293).

Cell & gene therapy

  • Feed & buffering supplements – Shear protection.
  • Vector Production / Transfection – Shear protection.
  • Ultrafiltration / Diafiltration – Membrane / shear protection.
  • Ultrafiltration / Diafiltration – Membrane protection.

Vaccines

  • Media supplements – Shear protection for suspension / bioreactor culture.

Liposomes & LNP

  • Solvent removal & buffer exchange – membrane / shear protection in TFF.

Frequently asked questions

In which grade is Pluronic® F-68 10 % available?

It is available as a RUO product (P08-02100); a matching GMP grade (CT-02110) is also available.

Which processes is this product used in?

Pluronic® F-68 10 % is used across the PAN monoclonal antibody, cell & gene therapy, vaccine and liposome & LNP processes. See "In the process – by application (upstream & downstream)" above for the specific steps in each.

One partner across every application. Explore the full GMP-grade catalogue or use the Smart Product Search.