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Upstream & Downstream

NaOH 1 M, Stock Solution

1 M sodium hydroxide stock for column cleaning-in-place (CIP), sanitisation and regeneration. · GMP catalogue product · CT-55105

GMP · CT-55105Downstream · DSP

NaOH 1 M Stock Solution is a defined sodium-hydroxide concentrate for downstream processing. It is the standard reagent for column cleaning-in-place (CIP), sanitisation and system regeneration between batches, diluted to the required working strength. As a GMP-grade stock it is used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy.

One GMP quality. NaOH 1 M, Stock Solution is a GMP-grade catalogue product (CT-55105), manufactured by PAN-Celltech and released against a defined quality-control panel on every lot.

Why

  • Standard CIP reagent - Cleaning, sanitisation and regeneration.
  • Concentrated 1 M - Dilute as required.
  • GMP grade - Catalogue GMP quality, released per lot.
  • Multi-application - Used across antibody, vaccine, mRNA and C&G downstream.

Specification

Composition1 M sodium hydroxide
FormStock concentrate
Storage15-25 °C (room temperature)
GradeGMP

Ordering

GradeArticle No.Pack size
GMPCT-55105500 ml

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Other pack sizes are available on request.

Beyond compendial - on request. Every PAN downstream buffer is also available in a beyond-compendial version produced with WFI Beyond - Water for Injection engineered beyond the Ph. Eur./USP monograph - for the most demanding endotoxin and purity requirements. Available on request.

In the downstream process - by application

NaOH 1 M, Stock Solution is used at the following process steps across the four biologics platforms:

Monoclonal antibodies

  • All chromatography columns (Protein A, IEX, HIC, SEC) - cleaning-in-place (CIP) and sanitisation.
  • System - regeneration between batches.

Vaccines

  • Chromatography and TFF systems - CIP and sanitisation.

mRNA

  • Chromatography / TFF systems - CIP and sanitisation.
  • Surfaces / equipment - alkaline nuclease decontamination.

Cell & gene therapy

  • Chromatography and TFF systems - CIP and sanitisation.
  • Plasmid DNA - alkaline-lysis component.

Frequently asked questions

What is NaOH 1 M Stock Solution used for?

It is used for column cleaning-in-place (CIP), sanitisation and system regeneration in downstream processing.

Is it multi-application?

Yes. It is a general CIP/sanitisation reagent used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy downstream.

One partner across every application. The same GMP downstream buffers support monoclonal antibodies, vaccines, mRNA and cell & gene therapy - explore the full GMP-grade catalogue or use the Smart Product Search.

Related: WFI Quality Water (CT-991500) · DPBS w/o Ca & Mg (CT-36500) · GMP-Grade Products