NaCl 5 M, stock solution
5 M sodium chloride stock concentrate for adjusting ionic strength across downstream chromatography. · GMP catalogue product · CT-77055
NaCl 5 M Stock Solution is a defined sodium-chloride concentrate for downstream processing. It is used to adjust ionic strength for equilibration, wash and salt-gradient elution across affinity, ion-exchange and hydrophobic-interaction chromatography. As a universal salt stock it is applied across monoclonal antibodies, vaccines, mRNA and cell & gene therapy.
One GMP quality. NaCl 5 M, stock solution is a GMP-grade catalogue product (CT-77055), manufactured by PAN-Celltech and released against a defined quality-control panel on every lot.
Why
- One salt across many steps – Equilibration, wash and salt-gradient elution.
- Concentrated 5 M – Flexible working strengths from a single stock.
- GMP grade – Catalogue GMP quality, released per lot.
- Multi-application – Used across antibody, vaccine, mRNA and C&G downstream.
Specification
| Composition | 5 M sodium chloride |
| Form | Stock concentrate |
| Storage | 15-25 °C (room temperature) |
| Grade | GMP |
Ordering
| Grade | Article No. | Pack size |
|---|---|---|
| GMP | CT-77055 | 500 ml |
Other pack sizes are available on request.
Beyond compendial – on request. Every PAN downstream buffer is also available in a beyond-compendial version produced with WFI Beyond – Water for Injection engineered beyond the Ph. Eur./USP monograph – for the most demanding endotoxin and purity requirements. Available on request.
In the process – by application (upstream & downstream)
NaCl 5 M, stock solution is used at the following process steps across the biologics platforms it supports:
Monoclonal antibodies
- Protein A capture – ionic-strength adjustment for equilibration and wash buffers.
- Ion exchange (CEX / AEX) – salt-gradient elution and wash.
- HIC – high-salt loading, elution and strip.
- Drug-substance formulation – tonicity (isotonicity) adjustment.
Vaccines
- Ion-exchange chromatography – salt-gradient elution and wash.
- HIC / conditioning – loading and salt conditioning of intermediates.
- Formulation – tonicity adjustment.
mRNA
- Anion-exchange / oligo-dT purification – salt binding and wash conditions.
- TFF / diafiltration – ionic-strength conditioning during buffer exchange.
- Formulation – tonicity adjustment.
Cell & gene therapy
- Anion-exchange (e.g. AAV full/empty separation) – salt-gradient elution.
- Affinity capture wash – ionic-strength adjustment.
- TFF / conditioning – salt conditioning.
- Formulation – tonicity adjustment.
Frequently asked questions
What is NaCl 5 M Stock Solution used for?
It adjusts ionic strength for equilibration, wash and salt-gradient elution across chromatography steps.
Is it multi-application?
Yes. It is a universal salt concentrate used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy downstream.
One partner across every application. The same GMP downstream buffers support monoclonal antibodies, vaccines, mRNA and cell & gene therapy – explore the full GMP-grade catalogue or use the Smart Product Search.
Related: WFI Quality Water (CT-991500) · DPBS w/o Ca & Mg (CT-36500) · GMP-Grade Products