Histidine 100 mM
100 mM histidine buffer for polishing and final formulation of biologics. · GMP catalogue product · CT-69510
Histidine 100 mM is a defined histidine buffer for downstream processing. It is used for size-exclusion (SEC) polishing and, most importantly, as the standard final-formulation buffer for many biologics. As a GMP-grade buffer it is applied across monoclonal antibodies, vaccines, mRNA and cell & gene therapy.
Why
- Standard formulation base - The common histidine formulation buffer for biologics.
- Polishing & formulation - SEC polishing plus final formulation.
- GMP grade - Catalogue GMP quality, released per lot.
- Multi-application - Used across antibody and C&G formulation.
Specification
| Composition | 100 mM histidine |
| Form | Ready-to-use buffer |
| Storage | 15-25 °C (room temperature) |
| Grade | GMP |
Ordering
| Grade | Article No. | Pack size |
|---|---|---|
| GMP | CT-69510 | 100 ml |
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Other pack sizes are available on request.
In the downstream process - by application
Histidine 100 mM is used at the following process steps across the four biologics platforms:
Monoclonal antibodies
- SEC polishing - running buffer.
- Drug-substance formulation - primary final-formulation buffer.
Vaccines
- Formulation - buffering.
mRNA
- Final drug-product / LNP formulation - formulation buffering.
Cell & gene therapy
- Vector final formulation - formulation buffering.
Frequently asked questions
What is Histidine 100 mM used for?
It is used for SEC polishing and as a standard final-formulation buffer for biologics.
Is it multi-application?
Yes, it is used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy downstream, wherever a histidine formulation buffer is required.
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