HEPES Buffer 1 M, GMP grade
Process liquid / buffer · RUO (P05-01100) · GMP (CT-01100)
HEPES Buffer 1 M, GMP grade – a concentrated zwitterionic organic buffer for stable pH control during cell handling, wash and open-system (non-CO₂) work.
Catalogue and GMP grade. HEPES Buffer 1 M is a RUO product (P05-01100); a matched GMP grade (CT-01100) is also available. Both are manufactured or assured by PAN-Celltech and released against a defined quality-control panel on every lot.
Why
- Stable pH – reliable buffering outside CO₂ incubation.
- Concentrated 1 M – add to media/buffers as needed.
- Cell-friendly – widely used zwitterionic buffer.
Specification
| Composition | 1 M HEPES |
| Form | Concentrated solution |
| Grade | RUO and GMP |
| Storage | 15-25 °C (room temperature) |
Ordering
Beyond compendial – on request. Like every PAN process liquid, HEPES Buffer 1 M, GMP grade can be prepared with WFI Beyond – Water for Injection engineered beyond the Ph. Eur./USP monograph – for the most demanding endotoxin and purity requirements. Available on request.
In the process – by application (upstream & downstream)
HEPES Buffer 1 M, GMP grade is used at the following process steps across the biologics platforms it supports:
Monoclonal antibodies
- Bioreactor Production (Fed-batch / Perfusion) – PH stabilisation for bioreactor sampling and media handling outside incubator.
Cell & gene therapy
- Feed & buffering supplements – Neutral-pH buffering.
Vaccines
- Media supplements – pH buffering (CO₂-independent handling).
mRNA
- RNA Purification – Buffer base. RUO: P05-01100.
- Solvent Removal / TFF – Exchange buffer. RUO: P05-01100.
Liposomes & LNP
- Aqueous / buffer preparation and size reduction – hydration buffer at physiological pH and running buffer.
Frequently asked questions
In which grade is HEPES Buffer 1 M available?
It is available as a RUO product (P05-01100); a matching GMP grade (CT-01100) is also available.
Which processes is this product used in?
HEPES Buffer 1 M, GMP grade is used across the PAN monoclonal antibody, cell & gene therapy, vaccine, mRNA and liposome & LNP processes. See "In the process – by application (upstream & downstream)" above for the specific steps in each.
One partner across every application. Explore the full GMP-grade catalogue or use the Smart Product Search.