Pluronic® F-68 10 %, GMP grade
Process liquid / additive · RUO (P08-02100) · GMP (CT-02110)
Pluronic® F-68 10 % – a non-ionic surfactant that protects cells from shear stress in suspension and bioreactor culture and during ultrafiltration.
Catalogue and GMP grade. Pluronic® F-68 10 % is a RUO product (P08-02100); a matched GMP grade (CT-02110) is also available. Both are manufactured or assured by PAN-Celltech and released against a defined quality-control panel on every lot.
Why
- Shear protection – for suspension and bioreactor systems.
- GMP grade – for regulated manufacture.
- Non-ionic surfactant – 10 % solution.
Specification
| Composition | 10 % Poloxamer 188 (Pluronic® F-68) |
| Form | Solution |
| Grade | RUO and GMP |
| Storage | 15-25 °C (room temperature) |
Ordering
Beyond compendial – on request. Like every PAN process liquid, Pluronic® F-68 10 % can be prepared with WFI Beyond – Water for Injection engineered beyond the Ph. Eur./USP monograph – for the most demanding endotoxin and purity requirements. Available on request.
In the process – by application (upstream & downstream)
Pluronic® F-68 10 % is used at the following process steps across the biologics platforms it supports:
Monoclonal antibodies
- CHO – Shear protectant in stirred bioreactors and shake flasks. Not needed for HybridBoost/ISF-1 (surfactant built in).
- HEK – Shear protectant in stirred bioreactors and shake flasks. Not needed for HybridBoost/ISF-1 (surfactant built in).
- Hybridoma – Shear protectant in stirred bioreactors and shake flasks. Not needed for HybridBoost/ISF-1 (surfactant built in).
- Bioreactor Production (Fed-batch / Perfusion) – Continuous shear protection in sparged bioreactors (CHO/HEK293).
Cell & gene therapy
- Feed & buffering supplements – Shear protection.
- Vector Production / Transfection – Shear protection.
- Ultrafiltration / Diafiltration – Membrane / shear protection.
- Ultrafiltration / Diafiltration – Membrane protection.
Vaccines
- Media supplements – Shear protection for suspension / bioreactor culture.
Liposomes & LNP
- Solvent removal & buffer exchange – membrane / shear protection in TFF.
Frequently asked questions
In which grade is Pluronic® F-68 10 % available?
It is available as a RUO product (P08-02100); a matching GMP grade (CT-02110) is also available.
Which processes is this product used in?
Pluronic® F-68 10 % is used across the PAN monoclonal antibody, cell & gene therapy, vaccine and liposome & LNP processes. See "In the process – by application (upstream & downstream)" above for the specific steps in each.
One partner across every application. Explore the full GMP-grade catalogue or use the Smart Product Search.