Sodium acetate 100 mM, pH 4.5
Ready-to-use 100 mM sodium acetate buffer at pH 4.5 for cation-exchange and formulation. · GMP catalogue product · CT-76451
Sodium acetate 100 mM, pH 4.5 is a defined, ready-to-use acetate buffer. In downstream processing it serves as a cation-exchange (CEX) equilibration and wash buffer and as a base for UF/DF and formulation. With a fixed composition and pH it is used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy.
One GMP quality. Sodium acetate 100 mM, pH 4.5 is a GMP-grade catalogue product (CT-76451), manufactured by PAN-Celltech and released against a defined quality-control panel on every lot.
Why
- Defined acetate base – Fixed pH 4.5 ± 0.2.
- Chromatography & formulation – CEX plus UF/DF and formulation.
- GMP grade – Catalogue GMP quality, released per lot.
- Multi-application – Used across antibody, vaccine and C&G downstream.
Specification
| Composition | 100 mM sodium acetate |
| pH | 4.5 ± 0.2 |
| Form | Ready-to-use buffer |
| Storage | 15-25 °C (room temperature) |
| Grade | GMP |
Ordering
| Grade | Article No. | Pack size |
|---|---|---|
| GMP | CT-76451 | 500 ml |
Other pack sizes are available on request.
Beyond compendial – on request. Every PAN downstream buffer is also available in a beyond-compendial version produced with WFI Beyond – Water for Injection engineered beyond the Ph. Eur./USP monograph – for the most demanding endotoxin and purity requirements. Available on request.
In the process – by application (upstream & downstream)
Sodium acetate 100 mM, pH 4.5 is used at the following process steps across the biologics platforms it supports:
Monoclonal antibodies
- Cation exchange (CEX) – equilibration and wash buffer base.
- UF/DF and formulation – acetate buffer base.
Vaccines
- Ion-exchange chromatography – buffer base.
- Formulation – buffer base.
mRNA
- LNP formulation – low-pH mixing buffer (acetate system).
- Formulation – buffering.
Cell & gene therapy
- Cation / ion exchange – buffer base.
- Formulation – buffer base.
Frequently asked questions
What is Sodium acetate 100 mM, pH 4.5 used for?
It is used for cation-exchange (CEX) equilibration/wash and as a base for UF/DF and formulation.
What is the pH?
It is supplied at a fixed pH of 4.5 ± 0.2.
Is it multi-application?
Yes, it is used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy downstream.
One partner across every application. The same GMP downstream buffers support monoclonal antibodies, vaccines, mRNA and cell & gene therapy – explore the full GMP-grade catalogue or use the Smart Product Search.
Related: WFI Quality Water (CT-991500) · DPBS w/o Ca & Mg (CT-36500) · GMP-Grade Products