NaCl 5 M, Stock Solution
5 M sodium chloride stock concentrate for adjusting ionic strength across downstream chromatography. · GMP catalogue product · CT-77055
NaCl 5 M Stock Solution is a defined sodium-chloride concentrate for downstream processing. It is used to adjust ionic strength for equilibration, wash and salt-gradient elution across affinity, ion-exchange and hydrophobic-interaction chromatography. As a universal salt stock it is applied across monoclonal antibodies, vaccines, mRNA and cell & gene therapy.
Why
- One salt across many steps - Equilibration, wash and salt-gradient elution.
- Concentrated 5 M - Flexible working strengths from a single stock.
- GMP grade - Catalogue GMP quality, released per lot.
- Multi-application - Used across antibody, vaccine, mRNA and C&G downstream.
Specification
| Composition | 5 M sodium chloride |
| Form | Stock concentrate |
| Storage | 15-25 °C (room temperature) |
| Grade | GMP |
Ordering
| Grade | Article No. | Pack size |
|---|---|---|
| GMP | CT-77055 | 500 ml |
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Other pack sizes are available on request.
In the downstream process - by application
NaCl 5 M, Stock Solution is used at the following process steps across the four biologics platforms:
Monoclonal antibodies
- Protein A capture - ionic-strength adjustment for equilibration and wash buffers.
- Ion exchange (CEX / AEX) - salt-gradient elution and wash.
- HIC - high-salt loading, elution and strip.
- Drug-substance formulation - tonicity (isotonicity) adjustment.
Vaccines
- Ion-exchange chromatography - salt-gradient elution and wash.
- HIC / conditioning - loading and salt conditioning of intermediates.
- Formulation - tonicity adjustment.
mRNA
- Anion-exchange / oligo-dT purification - salt binding and wash conditions.
- TFF / diafiltration - ionic-strength conditioning during buffer exchange.
- Formulation - tonicity adjustment.
Cell & gene therapy
- Anion-exchange (e.g. AAV full/empty separation) - salt-gradient elution.
- Affinity capture wash - ionic-strength adjustment.
- TFF / conditioning - salt conditioning.
- Formulation - tonicity adjustment.
Frequently asked questions
What is NaCl 5 M Stock Solution used for?
It adjusts ionic strength for equilibration, wash and salt-gradient elution across chromatography steps.
Is it multi-application?
Yes. It is a universal salt concentrate used across monoclonal antibodies, vaccines, mRNA and cell & gene therapy downstream.
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