![Expanded Portfolio Expanded Portfolio](https://www.pan-biotech.com/wp-content/uploads/2024/05/Bannerbild_Expanded_Portfolio_1920_x_380_px_70f683ac00.webp)
![expanded portfolio expanded portfolio](https://www.pan-biotech.com/wp-content/uploads/2024/06/expanded-portfolio.webp)
Expanded Portfolio
With over 35 years of experience in the development and manufacturing of cell culture media, we have expanded our portfolio to include a wide range of GMP-grade sterile liquids for biotechnological and biopharmaceutical applications. Here are some examples of our customized solutions for bioproduction and molecular diagnostics, produced in our new facility, built and qualified according to EU GMP Annex 1.
![](https://www.pan-biotech.com/wp-content/uploads/2024/07/Ubersichtsbild_Sample04_fur-Webshop_TSB.webp)
TSB Medium
Tryptic soy broth (TSB) medium is a nutrient-rich liquid growth medium that promotes the growth of a variety of microorganisms, including aerobes and facultative anaerobes. TSB is a general-purpose medium referenced in the European Pharmacopeia (EP) and the United States Pharmacopeia (USP) and is mainly used in pharmaceutical manufacturing, e.g. in sterility testing and media fill applications. We provide non-animal origin TSB medium in GMP-grade, designed for high quality standards of the biopharmaceutical industry. Application areas of our TSB medium include sterility testing, media fill tests, validation of sterilization procedures, environmental monitoring and equipment validation.
![TSB MEDIUM TSB MEDIUM](https://www.pan-biotech.com/wp-content/uploads/2024/07/Ubersichtsbild_Sample04_fur-Webshop_TSB.webp)
TSB Medium
Tryptic soy broth (TSB) medium is a nutrient-rich liquid growth medium that promotes the growth of a variety of microorganisms, including aerobes and facultative anaerobes. TSB is a general-purpose medium referenced in the European Pharmacopeia (EP) and the United States Pharmacopeia (USP) and is mainly used in pharmaceutical manufacturing, e.g. in sterility testing and media fill applications. We provide non-animal origin TSB medium in GMP-grade, designed for high quality standards of the biopharmaceutical industry. Application areas of our TSB medium include sterility testing, media fill tests, validation of sterilization procedures, environmental monitoring and equipment validation.
PBS Solutions
Phosphate-buffered saline (PBS) is a well-known water-based buffer solution (pH ~ 7.4) containing disodium hydrogen phosphate, sodium chloride and, in some formulations, potassium chloride and potassium dihydrogen phosphate. It helps to maintain a stable pH and osmotic pressure environment in the physiological range. It also has isotonic and non-toxic properties which makes PBS solutions well-suited for maintaining the viability of mammalian cells in vitro. We manufacture our GMP-grade PBS solutions according to your individual requirements, such as special formulations or packaging. Our PBS buffers are perfectly suited for upstream process development in the bioproduction of therapeutical proteins and monoclonal antibodies or for vaccine manufacturing. In cell and gene therapy, our high quality buffers find their use amongst others in downstream processing of advanced therapy medicinal products (ATMPs).
![](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_PBS.webp)
![PBS Solution PBS Solution](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_PBS.webp)
PBS Solutions
Phosphate-buffered saline (PBS) is a well-known water-based buffer solution (pH ~ 7.4) containing disodium hydrogen phosphate, sodium chloride and, in some formulations, potassium chloride and potassium dihydrogen phosphate. It helps to maintain a stable pH and osmotic pressure environment in the physiological range. It also has isotonic and non-toxic properties which makes PBS solutions well-suited for maintaining the viability of mammalian cells in vitro. We manufacture our GMP-grade PBS solutions according to your individual requirements, such as special formulations or packaging. Our PBS buffers are perfectly suited for upstream process development in the bioproduction of therapeutical proteins and monoclonal antibodies or for vaccine manufacturing. In cell and gene therapy, our high quality buffers find their use amongst others in downstream processing of advanced therapy medicinal products (ATMPs).
![](https://www.pan-biotech.com/wp-content/uploads/2024/05/P05_39500_6eac8ef7ea.webp)
Sodium Chloride Solutions
Sodium chloride (NaCl) solutions are commonly used in pharmaceutical, biopharmaceutical and diagnostic industries. The concentration and specific use can vary depending on the particular bioprocessing application and the requirements of the product being developed. According to customer requirements, we offer NaCl solutions in various concentrations and packaging options. PAN-Biotech’s GMP-grade NaCl solutions guarantee consistency and reliability for use in various stages of bioprocessing (up- and downstream), especially in the fields of biotechnology and pharmaceutical manufacturing. They are used in media and buffer preparation, protein purification, dialysis and desalting, cell harvesting and cell lysis, stabilization and storage of biomolecules or salt gradient chromatography.
![P05_39500_6eac8ef7ea Sodium Chloride](https://www.pan-biotech.com/wp-content/uploads/2024/05/P05_39500_6eac8ef7ea.webp)
Sodium Chloride Solutions
Sodium chloride (NaCl) solutions are commonly used in pharmaceutical, biopharmaceutical and diagnostic industries. The concentration and specific use can vary depending on the particular bioprocessing application and the requirements of the product being developed. According to customer requirements, we offer NaCl solutions in various concentrations and packaging options. PAN-Biotech’s GMP-grade NaCl solutions guarantee consistency and reliability for use in various stages of bioprocessing (up- and downstream), especially in the fields of biotechnology and pharmaceutical manufacturing. They are used in media and buffer preparation, protein purification, dialysis and desalting, cell harvesting and cell lysis, stabilization and storage of biomolecules or salt gradient chromatography.
Tris Buffer Solutions
Tris (2-Amino-2-(hydroxymethyl)propane-1,3-diol) buffer solutions are versatile buffers, essential for many applications in biochemistry, molecular biology, microbiology and the pharmaceutical industry. Tris has a buffering capacity in the range of pH 7.2 – 9.0, which corresponds to the physiological pH value of many living organisms. In industrial bioproduction, Tris buffers play a significant role in various stages of biomolecule downstream processing. Those include steps like nucleic acid and protein purification, protein solubilization, virus inactivation, buffer exchange, stabilization of biomolecules, lyophilization, tangential flow filtrations and final formulation. We provide GMP-grade Tris buffer solutions, which are available as customized formulations with individual Tris concentrations.
![](https://www.pan-biotech.com/wp-content/uploads/2024/05/P05_05500_3f4199cea6.webp)
![P05_05500_3f4199cea6 Tris Buffer](https://www.pan-biotech.com/wp-content/uploads/2024/05/P05_05500_3f4199cea6.webp)
Tris Buffer Solutions
Tris (2-Amino-2-(hydroxymethyl)propane-1,3-diol) buffer solutions are versatile buffers, essential for many applications in biochemistry, molecular biology, microbiology and the pharmaceutical industry. Tris has a buffering capacity in the range of pH 7.2 – 9.0, which corresponds to the physiological pH value of many living organisms. In industrial bioproduction, Tris buffers play a significant role in various stages of biomolecule downstream processing. Those include steps like nucleic acid and protein purification, protein solubilization, virus inactivation, buffer exchange, stabilization of biomolecules, lyophilization, tangential flow filtrations and final formulation. We provide GMP-grade Tris buffer solutions, which are available as customized formulations with individual Tris concentrations.
![](https://www.pan-biotech.com/wp-content/uploads/2024/05/Uebersichtsbild_EDTA_fuer_Webshop_e80358a209.webp)
EDTA Solutions
Ethylene diamine tetra-acetic acid (EDTA) is an aminopolycarboxylic acid that forms particularly stable chelate complexes with cations possessing a charge number of at least +2. EDTA solutions are primarily used to chelate divalent cations like calcium (Ca2+) and magnesium (Mg2+) which is important for several applications in bioprocessing. In biomolecule downstream processing, ETDA is used for buffer preparations when stabilization of metal-sensitive enzymes is necessary or to remove contaminating metal ions. Also, for cell culturing applications EDTA solutions are used for detachment of adherent cells for routine passaging. The concentration of EDTA should be tailored to the specific requirements of the processes and the desired results. We offer customized EDTA solutions in GMP-grade that meet the requirements of diverse biopharma and bioproduction applications.
![Uebersichtsbild_EDTA_fuer_Webshop_e80358a209 EDTA](https://www.pan-biotech.com/wp-content/uploads/2024/05/Uebersichtsbild_EDTA_fuer_Webshop_e80358a209.webp)
EDTA Solutions
Ethylene diamine tetra-acetic acid (EDTA) is an aminopolycarboxylic acid that forms particularly stable chelate complexes with cations possessing a charge number of at least +2. EDTA solutions are primarily used to chelate divalent cations like calcium (Ca2+) and magnesium (Mg2+) which is important for several applications in bioprocessing. In biomolecule downstream processing, ETDA is used for buffer preparations when stabilization of metal-sensitive enzymes is necessary or to remove contaminating metal ions. Also, for cell culturing applications EDTA solutions are used for detachment of adherent cells for routine passaging. The concentration of EDTA should be tailored to the specific requirements of the processes and the desired results. We offer customized EDTA solutions in GMP-grade that meet the requirements of diverse biopharma and bioproduction applications.
Ammonium Sulfate Solutions
Ammonium sulfate ((NH4)2SO4) is an inorganic salt characterized by a particular high solubility in aqueous solutions, which enables the production of highly concentrated solutions. It is of central importance in the biopharmaceutical industry, commonly used in ammonium sulfate precipitations. This is a widely applied method for protein purification and fractionation, both on industrial and laboratory scale. In this process, proteins are separated by changing their solubility at different salt concentrations. We manufacture GMP-grade ammonium sulfate solutions tailored to your individual needs. Covering the diverse requirements of the biopharmaceutical industry, we offer various concentrations and combinations with other buffer solutions. Applications include monoclonal antibody production and purification, vaccine production, nucleic acid purification, exosome isolation, hormone extraction or peptide synthesis.
![](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_Ammonium-sulfate.webp)
![Ammonium Sulfate Ammonium Sulfate](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_Ammonium-sulfate.webp)
Ammonium Sulfate Solutions
Ammonium sulfate ((NH4)2SO4) is an inorganic salt characterized by a particular high solubility in aqueous solutions, which enables the production of highly concentrated solutions. It is of central importance in the biopharmaceutical industry, commonly used in ammonium sulfate precipitations. This is a widely applied method for protein purification and fractionation, both on industrial and laboratory scale. In this process, proteins are separated by changing their solubility at different salt concentrations. We manufacture GMP-grade ammonium sulfate solutions tailored to your individual needs. Covering the diverse requirements of the biopharmaceutical industry, we offer various concentrations and combinations with other buffer solutions. Applications include monoclonal antibody production and purification, vaccine production, nucleic acid purification, exosome isolation, hormone extraction or peptide synthesis.
![](https://www.pan-biotech.com/wp-content/uploads/2024/07/Potassium-Acetate-Solutions.webp)
Potassium Acetate Solutions
Potassium acetate is the potassium salt of acetic acid and shows a high solubility in aqueous solutions. Potassium acetate solutions play a crucial role in various life science applications including bioproduction and bioprocessing. Amongst others it is used for precipitation of DNA and RNA and for buffering in the pH range of 3.8 – 5.8. Whether you require a specific concentration or a combination with other buffer solutions, we offer potassium acetate solutions in GMP-grade tailored to your specifications. They are applied in various life science tasks like DNA/RNA extraction, cryopreservation, cell culture media formulation and stabilizing vectors in gene therapy applications.
![Potassium Acetate Solutions Potassium Acetate Solutions](https://www.pan-biotech.com/wp-content/uploads/2024/07/Potassium-Acetate-Solutions.webp)
Potassium Acetate Solutions
Potassium acetate is the potassium salt of acetic acid and shows a high solubility in aqueous solutions. Potassium acetate solutions play a crucial role in various life science applications including bioproduction and bioprocessing. Amongst others it is used for precipitation of DNA and RNA and for buffering in the pH range of 3.8 – 5.8. Whether you require a specific concentration or a combination with other buffer solutions, we offer potassium acetate solutions in GMP-grade tailored to your specifications. They are applied in various life science tasks like DNA/RNA extraction, cryopreservation, cell culture media formulation and stabilizing vectors in gene therapy applications.
Basal Media such as M199, Alpha MEM (αMEM)
Basal media contain essential nutrients, salts and energy sources to support the growth and maintenance of cells in an industrial or laboratory setting. These media typically contain amino acids, vitamins, minerals, and carbohydrates necessary for cell proliferation. The choice of media is essential for maintaining healthy cells and thus determines the efficiency, accuracy and reproducibility of cell culture applications, for example in bioproduction. We offer a wide range of chemically defined basal media in GMP-grade that meet the highest standards. Those include M199 and Alpha MEM media that are used in a variety of upstream processes like vaccine production, gene and cell therapy, tissue engineering and regenerative medicine or monoclonal antibody production.
![](https://www.pan-biotech.com/wp-content/uploads/2024/05/Uebersichtsbild_basal_media_m199_fuer_Webshop_0a3a1eac61.webp)
![Uebersichtsbild_basal_media_m199_fuer_Webshop_0a3a1eac61 Basal Media](https://www.pan-biotech.com/wp-content/uploads/2024/05/Uebersichtsbild_basal_media_m199_fuer_Webshop_0a3a1eac61.webp)
Basal Media such as M199, Alpha MEM (αMEM)
Basal media contain essential nutrients, salts and energy sources to support the growth and maintenance of cells in an industrial or laboratory setting. These media typically contain amino acids, vitamins, minerals, and carbohydrates necessary for cell proliferation. The choice of media is essential for maintaining healthy cells and thus determines the efficiency, accuracy and reproducibility of cell culture applications, for example in bioproduction. We offer a wide range of chemically defined basal media in GMP-grade that meet the highest standards. Those include M199 and Alpha MEM media that are used in a variety of upstream processes like vaccine production, gene and cell therapy, tissue engineering and regenerative medicine or monoclonal antibody production.
![](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_Acetic-Acid.webp)
Acetic Acid Solutions
Acetic acid is a simple organic carboxylic acid that is used in a variety of biopharmaceutical applications and bioproduction processes. A common use is for pH control to maintain a stable pH in bioreactors and fermentation processes for optimal growth of microorganisms or cells. Acetic acid can also serve as a solvent for extraction of bioactive compounds. Furthermore, it is used in downstream processing purification steps like protein precipitation and crystallization. Whether it requires specific concentrations or a combination with other buffer solutions, we offer manufacturing services for GMP-grade acetic acid solutions tailored to your specific applications and needs.
![Acetic Acid Acetic Acid](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_Acetic-Acid.webp)
Acetic Acid Solutions
Acetic acid is a simple organic carboxylic acid that is used in a variety of biopharmaceutical applications and bioproduction processes. A common use is for pH control to maintain a stable pH in bioreactors and fermentation processes for optimal growth of microorganisms or cells. Acetic acid can also serve as a solvent for extraction of bioactive compounds. Furthermore, it is used in downstream processing purification steps like protein precipitation and crystallization. Whether it requires specific concentrations or a combination with other buffer solutions, we offer manufacturing services for GMP-grade acetic acid solutions tailored to your specific applications and needs.
RNase- / DNase- free WFI-Quality Water
PAN-Biotech’s WFI quality water is processed in a validated Water for Injection (WFI) system. A stack of purification processes like reverse osmosis, electrodeionization and ultrafiltration ensures that the stringent specifications of the European and United States Pharmacopeia (EP/USP) are met. Our WFI quality water is in compliance with regulatory requirements and suitable for a broad variety of up- and downstream applications. For special tasks in which the stability of RNA and DNA molecules is critical, it is important that used liquids are free of nucleases – which are enzymes that degrade nucleic acids. Our RNase- / DNase-free WFI quality water is ideally suited for these purposes. Applications include molecular diagnostics, PCR mixtures, RNA/DNA sequencing, gene therapy, CRISPR/Cas9 buffers, in vitro transcription and cDNA synthesis.
![](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_DNase_RNase_free_WFI_Quality_Water.webp)
![DNase-RNase free WFI Quality Water DNase-RNase free WFI Quality Water](https://www.pan-biotech.com/wp-content/uploads/2024/07/Sample_DNase_RNase_free_WFI_Quality_Water.webp)
RNase- / DNase- free WFI-Quality Water
PAN-Biotech’s WFI quality water is processed in a validated Water for Injection (WFI) system. A stack of purification processes like reverse osmosis, electrodeionization and ultrafiltration ensures that the stringent specifications of the European and United States Pharmacopeia (EP/USP) are met. Our WFI quality water is in compliance with regulatory requirements and suitable for a broad variety of up- and downstream applications. For special tasks in which the stability of RNA and DNA molecules is critical, it is important that used liquids are free of nucleases – which are enzymes that degrade nucleic acids. Our RNase- / DNase-free WFI quality water is ideally suited for these purposes. Applications include molecular diagnostics, PCR mixtures, RNA/DNA sequencing, gene therapy, CRISPR/Cas9 buffers, in vitro transcription and cDNA synthesis.
![](https://www.pan-biotech.com/wp-content/uploads/2024/05/Uebersichtsbild_Cryopan_II_fuer_Webshop_1dfe0cda9d.webp)
Cryopreservation Media: Cryopan II
Cryopreservation is the process of preserving cells, tissues and organs at very low temperatures. This method enables long-term storage of cells and seamless re-culturing at any given time or is used as preparation for transport procedures. The use of special cryopreservation media is crucial to protect cells in the freezing and thawing processes in laboratory applications as well as in industrial processing. We offer GMP-grade cryopreservation media such as Cryopan II. It is a serum- and protein-free freezing medium that is an ideal choice for the cryopreservation of a variety of cell types. Whether you are working with primary cells or established cell lines, this product ensures optimal cell preservation without the interference of human or animal components. The applications span across stem cell research and therapy, gene therapy, tissue engineering, biobanking, vaccine production as well as research and development.
![Uebersichtsbild_Cryopan_II_fuer_Webshop_1dfe0cda9d Cryopan](https://www.pan-biotech.com/wp-content/uploads/2024/05/Uebersichtsbild_Cryopan_II_fuer_Webshop_1dfe0cda9d.webp)
Cryopreservation Media: Cryopan II
Cryopreservation is the process of preserving cells, tissues and organs at very low temperatures. This method enables long-term storage of cells and seamless re-culturing at any given time or is used as preparation for transport procedures. The use of special cryopreservation media is crucial to protect cells in the freezing and thawing processes in laboratory applications as well as in industrial processing. We offer GMP-grade cryopreservation media such as Cryopan II. It is a serum- and protein-free freezing medium that is an ideal choice for the cryopreservation of a variety of cell types. Whether you are working with primary cells or established cell lines, this product ensures optimal cell preservation without the interference of human or animal components. The applications span across stem cell research and therapy, gene therapy, tissue engineering, biobanking, vaccine production as well as research and development.